PPD Tween (Tuberculin PPD)

Tuberculin Skin Test (TST), also known as the Mantoux test:

1. What is the Tuberculin Skin Test (TST)?
- The TST is a method used to determine if a person is infected with TB bacteria (Mycobacterium tuberculosis).
- In this test, a standardized solution made with purified protein derivative (PPD), derived from tuberculin, is injected under the skin.
- If a person has been infected with TB bacteria, PPD produces a T-cell mediated delayed-type hypersensitivity reaction.

2. Advantages and Disadvantages of the TB Skin Test:
- Advantages:
- Simple to perform (no need for laboratory equipment).
- Low cost.
- No phlebotomy required.
- Well-established definitions for TB skin test conversions.
- Legacy of clinical and epidemiological research.
- Disadvantages:
- Requires trained personnel for administration and interpretation.
- Correct refrigeration and inventory planning for the skin test solution.
- Previous BCG vaccination or infection with nontuberculous mycobacteria can cause false-positive results.
- Concurrent infections can cause false-negative results.
- Rare adverse effects.
- Can cause a booster phenomenon.
- Subject to biases and errors during placement and reading of the TB skin test.

3. Who Can Administer and Read TB Skin Tests?
- The TB skin test should be placed and read by a designated, trained health care provider.
- Consult with your state and local public health authorities to determine authorized personnel for TB skin test administration and reading.

4. Training Materials:
- Health care providers need training to administer and interpret the TB skin test.
- CDC provides free training materials, including fact sheets, wall charts, and videos, to enhance proficiency in TB skin test administration and interpretation.

Remember, if you have any specific concerns or need personalized advice, consult a healthcare professional.