Shingrix (Zoster Vaccine Recombinant, Adjuvanted)
Shingrix (Zoster Vaccine Recombinant, Adjuvanted)
SHINGRIX is a vaccine designed to prevent shingles (herpes zoster) in adults. It consists of two main components that need to be mixed before use:
1. gE Antigen Component: This is a lyophilized (freeze-dried) white powder containing the glycoprotein E (gE) antigen. The gE antigen is produced using genetically engineered Chinese Hamster Ovary (CHO) cells.
2. Adjuvant Suspension: This is a liquid that appears colorless to pale brownish. It enhances the immune response to the gE antigen.
The gE antigen is purified through several steps and combined with excipients before being freeze-dried. When ready to use, the gE antigen powder is reconstituted with the AS01B adjuvant suspension to form the final vaccine for intramuscular injection.
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