TPIAO (Recombinant Human Thrombopoietin)
TPIAO (Recombinant Human Thrombopoietin)
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TPIAO (Recombinant Human Thrombopoietin, rhTPO) is a synthetic version of thrombopoietin (TPO), a naturally occurring hormone responsible for stimulating the production of platelets (thrombocytes) in the bone marrow. It is used primarily to treat thrombocytopenia (low platelet count), which can occur due to conditions such as chemotherapy-induced bone marrow suppression, aplastic anemia, or immune thrombocytopenia (ITP).
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Mechanism of Action:
- TPO binds to the c-Mpl receptor on hematopoietic stem cells and megakaryocyte precursors in the bone marrow, promoting their proliferation, differentiation, and maturation into platelets.
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Clinical Uses:
- Chemotherapy-induced thrombocytopenia (CIT) – Helps restore platelet counts in cancer patients undergoing chemotherapy.
- Immune thrombocytopenia (ITP) – Used to increase platelet production in patients with chronic ITP.
- Aplastic anemia – Stimulates platelet production in patients with bone marrow failure.
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Differences from Other TPO Agonists:
- TPIAO is a full-length, glycosylated form of recombinant human thrombopoietin, making it more similar to endogenous TPO compared to other non-peptide TPO receptor agonists (e.g., eltrombopag, romiplostim).
- Unlike small-molecule TPO receptor agonists, TPIAO directly mimics natural TPO instead of acting as an artificial stimulator of the c-Mpl receptor.
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Administration:
- Typically given as an intravenous (IV) or subcutaneous (SC) injection, depending on the specific indication and patient condition.
- Dosage and treatment duration vary based on platelet levels and medical condition.
TPIAO (rhTPO) is an important treatment for thrombocytopenia, offering a natural approach to boosting platelet production. It is especially useful for patients with chemotherapy-induced platelet depletion and immune-related thrombocytopenia. While it has advantages over synthetic TPO receptor agonists, its use remains limited outside certain regions.
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