White-C (Filgrastim)

White-C (Filgrastim) is a colony-stimulating factor (CSF), specifically a recombinant form of human granulocyte colony-stimulating factor (G-CSF). It is used to stimulate the production of white blood cells (neutrophils) in the body, particularly after chemotherapy or bone marrow transplant, or in cases of neutropenia (low neutrophil count) caused by other conditions.

Key Details:

• Generic Name: Filgrastim

• Brand Name: White-C (one of several brand names, others include Neupogen, Zarzio, etc.)

• Form: Injection (usually subcutaneous or intravenous)

• Contents: Recombinant human G-CSF produced in E. coli.

Common Uses:

1. Cancer patients receiving chemotherapy – to reduce the risk of infection due to low white blood cell count.

2. Patients undergoing bone marrow/stem cell transplant – to help restore neutrophil levels.

3. Severe chronic neutropenia – to maintain adequate neutrophil levels.

4. AIDS patients – sometimes used off-label to treat neutropenia.

How it Works:

Filgrastim acts on the bone marrow to increase the production and release of neutrophils, which are essential for fighting infection.

Side Effects:

• Bone pain (common)

• Injection site reactions

• Headache

• Fever

• Fatigue

• Rare but serious: splenic rupture, allergic reactions, acute respiratory distress syndrome (ARDS)

Important Notes:

• Should only be used under a doctor’s supervision.

• Blood counts must be regularly monitored.

• Not recommended in patients with leukemia unless specifically indicated.