Aziro (Azithromycin Dihydrate)

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Contents:  Azithromycin Dihydrate

Description: Antibiotic azithromycin is used to treat a variety of bacterial illnesses. This covers pneumonia, traveler's diarrhea, strep throat, middle ear infections, and a few other intestinal ailments. Chlamydia and gonorrhea infections are just a couple of the sexually transmitted diseases for which it might be utilized. It might be used for malaria along with other drugs. Once daily doses can be administered intravenously or orally.

Indication/Use: for the treatment of simple vaginal infections, skin and soft tissue infections, and respiratory tract infections (including otitis media). Additionally used as part of regimens for the prophylaxis and treatment of Mycobacterium avium complex (MAC) infections.

Dosage: Adult-PO 500 mg once daily for 3 days for infections of the skin, respiratory tract, and soft tissues. or 250 mg on days 2 through 5 after taking 500 mg on day 1.
500 mg, once daily for seven days, for typhoid.
Simple gonorrhea: a single dose of 2 g.
Granuloma inguinale: 1 g at first, then 500 mg every day until all lesions have fully healed.
Chancroid/Chlamydial urethritis: 1 g single dosage; 1.2 g once weekly for the prevention of disseminated MAC infections. Administered along with other antimycobacterials: 500 mg once daily for treatment or secondary prevention.

Contraindication: Patients with known hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic should not take azithromycin. Patients who have a history of cholestatic jaundice or hepatic dysfunction linked to prior use of azithromycin should not be prescribed azithromycin.

Special Precaution: General: Patients with impaired hepatic function should take caution when using azithromycin because it is primarily excreted through the liver. When giving azithromycin to individuals who have a GFR of less than 10 mL/min, care should be taken due to the limited evidence in these subjects. Other macrolides have been used to treat cardiac arrhythmia and torsades de pointes, although they have also been associated with prolonged cardiac repolarization and QT interval. Azithromycin may have a comparable impact in those who are more likely to experience prolonged cardiac repolarization.
Myasthenia gravis symptoms worsening and a new start of the myasthenic syndrome have both been observed in patients using azithromycin.
Azithromycin prescriptions without a preventive indication, a confirmed or highly suspected bacterial infection is unlikely to assist the patient and raises the danger of bacteria becoming drug-resistant to antibiotics. Patients should know that they can take azithromycin pills with or without food. Additionally, patients should be advised not to take azithromycin and antacids that include magnesium and aluminum at the same time. In the event that any symptoms of an allergic reaction appear, the patient should be instructed to stop taking azithromycin right away and call their doctor. Azithromycin and other antibacterial medications should only be used to treat bacterial infections, patients should be advised. Viral infections are not treated by them (e.g., the common cold). Patients should be informed when azithromycin is administered to treat a bacterial infection that, despite it being typical to feel better early in the course of therapy, the medication must be taken exactly as prescribed. Missing doses or failing to finish the entire (1) decreasing the effectiveness of the immediate therapy and (2) raising the possibility that bacteria will acquire resistance and eventually become resistant to azithromycin and other antibacterial medications. Antibiotics frequently produce diarrhea, a symptom that typically goes away once the drug is stopped. Sometimes, even up to two or more months after the last dose of the antibiotic, patients who have begun antibiotic therapy may experience watery and bloody stools (with or without fever and stomach cramps). Patients should get in touch with their doctors right away if this happens.

Pregnancy & Lactation: Mothers who are nursing: It is unknown if azithromycin is excreted in breast milk. When giving azithromycin to a nursing mother, caution should be taken because many medications are secreted in human milk.