Claryn (Clarithromycin)

Indications: 

• Respiratory tract infections
• Mild to moderate skin & soft tissue infections
• Otitis media
• Helicobacter pylori eradication.

By mouth, 250 mg every 12 hours for seven days; for severe infections, 500 mg every 12 hours for up to 14 days; for children under eight kilograms of body weight, 7.5 mg/kg twice daily; and for eight to eleven kilograms (1-2 years). 125 mg twice daily; 20-29 kg; 62.5 mg twice daily; 12-19 kg (3-6 years); (7-9 years). 30-40kg (10-12 years): 250 mg twice daily or as needed; 187.5 mg twice daily; or as prescribed by a doctor. 

Administration:

Standard Release Tablet & Oral Suspension: May be taken with or without food.
Modified Release Tablet: Should be taken with food. Swallow whole, do not chew/crush

• Gastrointestinal disorders such as abdominal pain, diarrhea, nausea, vomiting, dysgeusia, dyspepsia
• Increased liver enzymes, hepatocellular hepatitis, and/or cholestatic hepatitis with or without jaundice are all signs of hepatic dysfunction
• CNS effects such as anxiety, dizziness, insomnia, hallucinations, confusion

Special Precaution:

Patients with compromised hepatic or renal function should use caution, and those with severe renal impairment should take lower doses.

Patients with known macrolide antibiotic hypersensitivity should not use clarithromycin.

Drug Interaction:

May increase blood levels of medicines metabolized by the CYP3A isozyme and inhibit their metabolism:

• alprazolam, astemizole, carbamazepine, cilostazol, cisapride, cyclosporine, disopyramide, ergot alkaloids, lovastatin, methylprednisolone, midazolam, omeprazole, warfarin, pimozide, quinidine, rifabutin, sildenafil, simvastatin, tacrolimus, terfenadine, triazolam, vinblastine; other isozymes of CYP450 eg, phenytoin, theophylline, valproate.

Storage: Store at temperatures not exceeding 30°C